The family of the Prime Minister indicated he was safe after a blast targeted his motorcade, CGTN Africa reports.
Images broadcast on regional TV channels and social media showed a convoy including several damaged white SUVs and a badly damaged car, Khaleej Times reports.
Three witnesses, the media also notes, said the attack happened near the northern entrance to Kober bridge, which connects Khartoum North with the city center.
Hamdok was heading to his office when the attack occurred.
The 64-year old 15th Prime Minister of Sudan was appointed last year head of the transition government in the wake of the overthrow of former and longtime President Omar Bashir who ruled the country for three decades.